Table 1.

Patient and disease characteristics and biomarker expression

	n (%)	Ki-67 (%)	CAIX	HIF1α	HIF2α	CRP
Sex
Male	139 (64.4)	0.63	0.190	0.096	0.111	0.167
Female	77 (35.6)	0.50	0.182	0.065	0.094	0.166
P		.513	.661	.027	.010	.954
RCC morphotype
Clear cell	156 (72.2)	0.35	0.234	0.072	0.099	0.167
Papillary	38 (17.6)	0.67	0.059	0.154	0.133	0.154
Chromophobe	16 (7.4)	0.02	0.033	0.066	0.082	0.181
Collecting duct	1 (0.5)	–	–	–	–	–
Unclassified	5 (2.3)	2.38	0.211	0.021	0.128	0.226
P		.012	<.0001	<.0001	<.0001	.869
ISUP grade
1	60 (30.6)	0.32	0.245	0.083	0.099	0.165
2	103 (52.6)	0.56	0.190	0.094	0.106	0.164
3	23 (11.7)	0.84	0.144	0.078	0.122	0.140
4	10 (5.1)	2.81	0.186	0.041	0.122	0.302
P		<.0001	.003	.445	.170	.145
Pathologic T stage
1	139 (64.4)	0.38	0.187	0.092	0.104	0.142
2	25 (11.6)	0.78	0.170	0.090	0.090	0.219
3a	43 (19.9)	0.98	0.184	0.069	0.115	0.217
3b	8 (3.7)	1.37	0.275	0.040	0.102	0.151
4	1 (0.5)	–	–	–	–	–
P		.026	.227	.356	.204	.068
Sarcomatoid de-differentiation	7 (3.2)
Venous thrombus present	31 (14.4)
Perinephric fat invasion	34 (16.7)
Tumor necrosis	11 (5.1)