. Author manuscript; available in PMC: 2015 Sep 1.

Published in final edited form as: Curr Osteoporos Rep. 2014 Sep;12(3):366–375. doi: 10.1007/s11914-014-0213-4

Table 1.

Extracellular proteins implicated in the control of bone ECM material properties

Protein	Reference
Ligands
vitamin D	13 14
TGFb	34
PTH	35 36
glucocorticoids	37
growth hormone	83, 84
IGF-1	83
Secreted Proteases
MMP2	71
MMP13	61
MMP9	71
Cathepsin K	72
Extracellular Matrix Proteins
osteocalcin	24
osteopontin	24, 25, 98, 99
collagen I	38–43
biglycan	26
Fibrillin	29
DMP1	27