In mice, experimental AP results in biochemical acute pancreatitis which at six hours shows a) elevated serum amylase and b) oedema, necrosis, and inflammatory cell infiltration in the pancreas at compared to c) sham-operated control mice (haematoxylin and eosin stain, ×200 magnification). By 24 hours following the induction of AP, d) there is still evidence of oedema, necrosis, and inflammatory cell infiltration in the pancreas compared to e) sham-operated control mice at the same time point. Haematoxylin and eosin stain, ×200 magnification.