Table 4.

Association of SBP and DBP with incident CVD across strata of walking speed

BP	N	Rate per 1000 PY	Demo Adjusted* HR (95% CI)	Adjusted** HR (95% CI)
SBP
Walking speed <0.60
SBP (per 10 mmHg increase)	303	81.6	1.07 (0.97, 1.18)	1.06 (0.96, 1.17)
SBP
≤ 120	56	66.7	1.00	1.00
121 – 150	174	80.8	1.26 (0.69, 2.32)	1.25 (0.67, 2.35)
> 150	73	97.6	1.49 (0.79, 2.92)	1.43 (0.69, 2.93)
Walking speed 0.60 – 0.99
SBP (per 10 mmHg increase)	1391	52.2	1.10 (1.05, 1.15)‡	1.10 (1.05, 1.16)‡
SBP
≤ 120	243	41.7	1.00	1.00
121 – 150	826	48.2	1.19 (0.91, 1.57)	1.30 (0.97, 1.73)
> 150	322	71.5	1.67 (1.23, 2.25)‡	1.81 (1.30, 2.51)‡
Walking speed ≥ 1.00
SBP (per 10 mmHg increase)	717	37.8	1.06 (1.00, 1.13)	1.07 (0.99, 1.16)
SBP
≤ 120	163	28.3	1.00	1.00
121 – 150	412	40.7	1.43 (0.98, 2.07)	1.37 (0.94, 2.04)
> 150	142	41.0	1.38 (0.88, 2.16)	1.36 (0.82, 2.24)
DBP
Walking speed <0.60
DBP (per 10 mmHg increase)	303	81.6	1.01 (0.84, 1.21)	0.94 (0.79, 1.13)
DBP
≤ 65	108	71.3	1.00	1.00
66 – 80	138	90.1	1.27 (0.81, 1.99)	1.07 (0.66, 1.72)
> 80	57	81.1	0.93 (0.48, 1.81)	0.66 (0.31, 1.38)
Walking speed 0.60 – 0.99
DBP (per 10 mmHg increase)	1391	52.2	1.04 (0.95, 1.13)	0.99 (0.90, 1.08)
DBP
≤ 65	433	55.1	1.00	1.00
66 – 80	752	46.9	0.89 (0.73, 1.10)	0.85 (0.68, 1.05)
> 80	117	66.0	1.29 (0.99, 1.69)	1.09 (0.80, 1.48)
Walking speed ≥ 1.00
DBP (per 10mmHg increase)	717	37.8	1.00(0.88, 1.14)	0.93 (0.80, 1.07)
DBP
≤ 65	213	41.9	1.00	1.00
66 – 80	387	36.6	0.93 (0.68, 1.27)	0.81 (0.58, 1.14)
> 80	117	34.9	0.83 (0.54, 1.28)	0.62 (0.37, 1.03)

^*adjusted for age, gender, race and education

^**Further adjusted smoking, physical activity, BMI, DM, total cholesterol, cystatin C and HTN meds and SBP or DBP, respectively. P-value for interaction SBP*walk=0.70, DBP*walk=0.59

^†p<0.05

^‡p<0.001