Table 1.
Baseline participant characteristics by stroke incidence (n=607)
| No Stroke (n=574) | Stroke (n=33)* | p-value | |
|---|---|---|---|
| Age (years) | 27.2 (7.8) | 33.4 (7.3) | <0.0001 |
| Age at onset (years) | 8.3 (4.1) | 7.8 (4.0) | 0.50 |
| Duration (years) | 19.0 (7.5) | 25.6 (6.5) | <0.0001 |
| Follow-up (years) | 18.6 (5.8) | 9.5 (7.0) | <0.0001 |
| Females (%, n) | 48.1 (276) | 48.5 (16) | 0.96 |
| Race / Ethnicity (%, n) | |||
| Non-Hispanic white | 97.9 (562) | 100.0 (33) | |
| African-American | 2.1 (12) | 0.0 (0) | 1.00 |
| Body mass index (kg/m2, n=572;33) | 23.6 (3.2) | 23.9 (3.3) | 0.57 |
| Waist to hip ratio (n=569;33) | 0.82 (0.07) | 0.85 (0.09) | 0.15 |
| Smoking, ever (%, n) | 36.1 (207) | 54.5 (18) | 0.03 |
| HbA1c (%) | 8.7 (1.5) | 9.0 (1.7) | 0.38 |
| HbA1c (mmol/mol) | 72 | 75 | |
| Systolic blood pressure (mmHg) | 112.8 (15.3) | 126.1 (18.0) | <0.0001 |
| Diastolic blood pressure (mmHg) | 72.4 (10.8) | 78.2 (13.7) | 0.02 |
| Hypertension (%, n) | 29.3 (168) | 57.6 (19) | 0.0006 |
| HDL cholesterol (mmol/L, n=571;32) | 1.4 (0.3) | 1.3 (0.3) | 0.49 |
| Non-HDL (mmol/L, n=571;32) | 3.5 (1.1) | 4.2 (1.2) | <0.0001 |
| Albumin excretion rate
(μg/min, n=570;32) |
14.1 (7.2-104.4) | 377.5 (17.8-1186.3) | <0.0001 |
| eGFR (mL/min/1.73 m2, n=573;33) | 103.2 (31.8) | 80.6 (37.0) | <0.0001 |
| White blood cell count ×
103/mm2 (n=570;33) |
6.5 (1.8) | 7.6 (2.4) | 0.01 |
*
9 hemorrhagic and 23 ischemic strokes