| TOR1 |
let-363 |
dTOR |
mTOR |
Vellai et al. (2003), Kapahi et al. (2004), Kaeberlein et al. (2005a, c), Powers et al. (2006) and Lamming et al. (2012)
|
| SCH9 |
rsks-1 |
dS6K |
S6K1 |
Fabrizio et al. (2004), Kapahi et al. (2004), Hansen et al. (2007), Pan et al. (2007) and Selman et al. (2009)
|
| SIR2 |
sir-2.1*
|
dSir2*
|
|
Kaeberlein et al. (1999), Tissenbaum & Guarente (2001), Rogina & Helfand (2004) and Burnett et al. (2011)
|
| RPD3 |
|
Rpd3 |
|
Kim et al. (1999), Jiang et al. (2002) and Rogina et al. (2002)
|
| DBP3 |
B0511.6 |
|
|
Curran & Ruvkun (2007) and Smith et al. (2008)
|
| PMR1 |
eat-6 |
|
|
Lakowski & Hekimi (1998) and Smith et al. (2008)
|
| YGR130C |
erm-1 |
|
|
Curran & Ruvkun (2007) and Smith et al. (2008)
|
| IDH1, IDH2 |
F43G9.1 |
|
|
Hamilton et al. (2005) and Smith et al. (2008)
|
| TIF4631 |
ifg-1 |
|
|
Curran & Ruvkun (2007), Pan et al. (2007) and Smith et al. (2008)
|
| TIF1, TIF2 |
inf-1 |
|
|
Curran & Ruvkun (2007) and Smith et al. (2008)
|
| PKH2 |
pdk-1 |
|
|
Paradis et al. (1999) and Smith et al. (2008)
|
| TIS11 |
pos-1 |
|
|
Curran & Ruvkun (2007) and Smith et al. (2008)
|
| YPT6 |
rab-10 |
|
|
Hansen et al. (2005) and Smith et al. (2008)
|
| RPL19A |
rpl-19 |
|
|
Hansen et al. (2007) and Smith et al. (2008)
|
| RPL6B |
rpl-6 |
|
|
Hansen et al. (2007) and Smith et al. (2008)
|
| RPL9A |
rpl-9 |
|
|
Hansen et al. (2007) and Smith et al. (2008)
|
| SAM1 |
sams-3 |
|
|
Curran & Ruvkun (2007) and Smith et al. (2008)
|
| HSE1 |
sem-5 |
|
|
Curran & Ruvkun (2007) and Smith et al. (2008)
|
| AFG3 |
spg-7 |
|
|
Curran & Ruvkun (2007), Smith et al. (2008) and Delaney et al. (2013a)
|
| SPT4 |
spt-4 |
|
|
Hamilton et al. (2005) and Smith et al. (2008)
|
| ALG12 |
T27F7.3 |
|
|
Curran & Ruvkun (2007) and Smith et al. (2008)
|
| INP51, INP53 |
unc-26 |
|
|
Lakowski & Hekimi (1998) and Smith et al. (2008)
|
| ADH1 |
W09H1.5 |
|
|
Hamilton et al. (2005) and Smith et al. (2008)
|
| SIS2 |
Y46H3C.6 |
|
|
Hamilton et al. (2005) and Smith et al. (2008)
|
| COX4 |
cco-1 |
|
|
Dillin et al. (2002) and Miceli et al. (2011)
|
| Intervention |
Worms |
Flies |
Rodents |
References |
| Dietary restriction |
X |
X |
X |
McCay et al. (1935), Klass (1977), Lakowski & Hekimi (1998), Lin et al. (2000), Mair et al. (2003) and Kaeberlein et al. (2006)
|
| Rapamycin |
X |
X |
X |
Medvedik et al. (2007), Harrison et al. (2009), Bjedov et al. (2010), Miller et al. (2011), Robida-Stubbs et al. (2012) and Wilkinson et al. (2012)
|
| Resveratrol*
|
X*
|
X*
|
|
Howitz et al. (2003), Wood et al. (2004), Kaeberlein et al. (2005d) and Bass et al. (2007)
|
| Spermidine |
X |
X |
|
Eisenberg et al. (2009) |
| Heat shock |
X |
X |
|
Lithgow et al. (1995), Khazaeli et al. (1997) and Shama et al. (1998)
|
