Table 3.

Hypothetical output of the knowledge base when queried for evidence of an association between drug X and renal failure. Bold text indicates hypothetical hyperlinks that will take the expert directly to more detailed information

Drug	ATC	HOI	Contra-indicated	US SPL	EU SmPC	Scientific literature	FDA FAERS	VigiBase®	EHR/Claims data
X	Beta blocker	Renal failure syndrome (disorder)	False	1 Renal failure (1998)	1 Renal failure acute (2001)	13 publications (1998–) Out of which: 3 case report (2001–) 2 RCTs (1998–) 8 observational studies (2003–) 0 systematic reviews	110 reports PRR: 4.5 Renal failure (April 1 2014)	148 reports PRR: 3.3 Renal failure (April 1 2014)	Associations: Medicare OR: 3.3 Medicaid OR: 2.2

ATC Anatomical Therapeutic Chemical Classification System, EHR electronic health record, EU European Union, FAERS FDA Adverse Event Reporting System, FDA US Food and Drug Administration, HOI health outcome of interest, OR odds ratio, PRR proportional reporting ratio, RCT randomized controlled trial, SmPC Summary of Product Characteristics, SPL Structured Product Labeling