Table 1.

Symptom-based clinical score (adapted from refs. [20, 23, 24])

Symptom	Score
Cryinga	0 to 6	0	1 h/day
		1	1–1.5 h/day
		2	1.5–2 h/day
		3	2 to 3 h/day
		4	3 to 4 h/day
		5	4 to 5 h/day
		6	>5 h/day
Regurgitation [22]	0 to 6	0	0–2 episodes/day
		1	>3 to <5 of small volume
		2	>5 episodes of >1 coffee spoon
		3	>5 episodes of ± half of the feedings in < half of the feedings
		4	Continuous regurgitations of small volumes >30 min after each feeding
		5	Regurgitation of half to complete volume of a feeding in at least half of the feedings
		6	Regurgitation of the complete volume after each feeding
Stools (according to Bristol stool scale [15])	0 to 6	4	Types 1 and 2 (hard stools)
		0	Types 3 and 4 (normal stools)
		2	Type 5 (soft stool)
		4	Type 6 (mushy/liquid stool, if unrelated to infection)
		6	Type 7 (watery stools)
Dermatological symptoms	0 to 6	Atopic eczema
			Head–neck–trunk	Arms–hands–legs–feet
		Absent	0	0
		Mild	1	1
		Moderate	2	2
		Severe	3	3
	0 to 6	Urticaria (0 no/6 yes)
Respiratory symptoms	0 to 3	0	No respiratory symptoms
		1	Mild symptoms
		2	Moderate symptoms
		3	Severe symptoms

^aCrying was only considered if the child was crying for 1 week or more, assessed by the parents, without any other obvious cause