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. 2014 Jun 12;111(4):716–725. doi: 10.1038/bjc.2014.325

Figure 1.

Figure 1

The chemical structures of MDM2-p53 antagonists Nutlin-3, NDD0005, MI-63, and RG7388, and MDR-1 expression in a panel of neuroblastoma cell lines established at relapse. (A) The chemical structures and corresponding IC50 values of Nutlin-3, NDD0005, MI-63 and RG7388. *This is the IC50 value for the active enantiomer Nutlin-3a. (B) Western blot analysis showing the expression levels of MDR-1, p53 and MYCN in p53 mutant (SKNBe2C, LAN1, SKNAS and IGRN91) and wt (SHSY5Y) neuroblastoma cell lines. MDCKII-MDR-1 cells are stably transfected with human MDR-1 and were used as a positive control. Actin was used as a loading control.