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. 2014 Jun 12;111(4):716–725. doi: 10.1038/bjc.2014.325

Figure 2.

Figure 2

Nutlin-3 sensitises high MDR-1-expressing p53 mutant neuroblastoma cell lines to vincristine but not cisplatin in a concentration-dependent manner. Sensitivity of high MDR-1-expressing SKNBe2C (A, C) and low MDR-1-expressing SKNAS cells (B, D) to treatment for 72 h with vincristine alone or in combination with 1, 2, or 5 μM verapamil or Nutlin-3, and (E) SKNBe2C and (F) SKNAS cells to treatment for 72 h with cisplatin alone or in combination with 1, 2 or 5 μM Nutlin-3. Data are shown as the average of at least three independent experiments and error bars represent s.e.m.