Table 3. Relationship between pSrc-Y416 and molecular biomarkers.
| Variables | All cases, n (%) | pSrcY416 (+), n (%) | pSrcY416 (−), n (%) | *P-value |
|---|---|---|---|---|
| Number |
278 (100) |
105 (37.8) |
173 (62.2) |
|
|
HR status | ||||
| Positive | 150 (54) | 51 (53.1 | 99 (57.6) | |
| Negative | 118 (42.4) | 45 (46.9) | 73 (42.4) | 0.483 |
| Unknown |
10 (3.6) |
|
|
|
|
p53 | ||||
| <20% | 174 (62.6) | 56 (56.6) | 118 (72.4) | |
| ⩾20% | 88 (31.7) | 43 (43.4) | 45 (27.6) | 0.009 |
| Unknown |
16 (5.8) |
|
|
|
|
Ki67 | ||||
| <14% | 95 (34.2) | 32 (33) | 63 (40.1) | |
| ⩾14% | 159 (57.2) | 65 (67) | 94 (59.9) | 0.253 |
| Unknown |
24 (8.6) |
|
|
|
|
PTEN | ||||
| Loss | 47 (16.9) | 15 (14.9) | 32 (18.9) | |
| Present | 224 (80.6) | 87 (85.3) | 137 (81.1) | 0.373 |
| Unknown |
7 (2.5) |
|
|
|
|
α-IGF1R | ||||
| No overexpression | 191 (68.7) | 69 (67) | 122 (74.8) | |
| Overexpression | 75 (27) | 34 (33) | 41 (25.2) | 0.165 |
| Unknown |
12 (4.3) |
|
|
|
|
EGFR | ||||
| Negative | 221 (79.5) | 93 (92.1) | 128 (79.5) | |
| Positive | 41 (14.7) | 8 (7.9) | 33 (20.5) | 0.006 |
| Unknown |
16 (5.8) |
|
|
|
|
PIK3CA
mut | ||||
| Negative | 201 (72.3) | 78 (86.7) | 123 (80.4) | |
| Positive | 42 (15.1) | 12 (13.3) | 30 (19.6) | 0.212 |
| Unknown |
35 (12.6) |
|
|
|
|
p110α | ||||
| No overexpression | 186 (66.9) | 64 (77.1) | 122 (85.3) | |
| Overexpression | 40 (14.4) | 19 (22.9) | 21 (14.7) | 0.119 |
| Unknown |
52 (18.7) |
|
|
|
|
pAkt | ||||
| No overexpression | 186 (66.9) | 63 (71.6) | 123 (77.8) | |
| Overexpression | 60 (21.6) | 25 (28.4) | 35 (22.2) | 0.273 |
| UNKNOWN |
32 (11.5) |
|
|
|
|
p-mTOR | ||||
| No overexpression | 161 (57.9) | 58 (56.9) | 103 (62.4) | |
| Overexpression | 106 (38.1) | 44 (43.1) | 62 (37.6) | 0.367 |
| Unknown |
11 (4) |
|
|
|
|
pMAPK | ||||
| No overexpression | 203 (73) | 61 (74.4) | 142 (92.8) | |
| Overexpression | 32 (11.5) | 21 (25.6) | 11 (7.2) | <0.000 |
| Unknown |
43 (15.5) |
|
|
|
|
p27 | ||||
| Loss | 89 (32) | 25 (26) | 64 (39.5) | |
| Present | 169 (60.8) | 71 (74) | 98 (60.5) | 0.028 |
| Unknown | 20 (7.2) | |||
Abbreviations: EGFR=epidermal growth factor receptor; HR=hormone receptor; IGF1R=insulin-like growth factor 1-receptor.
*All comparisons by Chi2 or Fisher tests.