Table 1. Association between p-PP2A and clinical and genetic parameters in 250 patients with metastatic CRC.
| No. of cases | No. p-PP2A− (%) | No. p-PP2A+ (%) | P | |
|---|---|---|---|---|
| p-PP2A |
250 |
207 (82.8) |
43 (17.2) |
|
| Sex |
250 |
207 |
43 |
0.018 |
| Male |
156 |
136 (87.2) |
20 (12.8) |
|
| Female |
94 |
71 (75.5) |
23 (24.5) |
|
| Age |
232 |
190 |
42 |
0.306 |
| <70 |
116 |
98 (84.5) |
18 (15.5) |
|
| ⩾70 |
116 |
92 (79.3) |
24 (20.7) |
|
| ECOG |
224 |
184 |
40 |
0.001 |
| 0–2 |
182 |
157 (84.5) |
25 (15.5) |
|
| 3–4 |
42 |
27 (64.3) |
15 (35.7) |
|
| Site of primary tumour |
250 |
207 |
43 |
0.552 |
| Cecum |
24 |
17 (84.5) |
7 (15.5) |
|
| Right colon |
37 |
31 (79.3) |
6 (20.7) |
|
| Transverse colon |
10 |
7 (70) |
3 (30) |
|
| Left colon |
21 |
18 (85.7) |
3 (14.3) |
|
| Sigma |
73 |
61 (83.6) |
12 (16.4) |
|
| Rectum |
85 |
73 (85.9) |
12 (14.1) |
|
| Synchronous metastasis |
244 |
201 |
43 |
0.035 |
| No |
85 |
76 (89.4) |
9 (10.6) |
|
| Yes |
159 |
125 (78.6) |
34 (21.4) |
|
| Number of metastatic sites |
250 |
207 |
43 |
0.620 |
| 1–2 |
226 |
188 (83.2) |
38 (16.8) |
|
| >2 |
24 |
19 (79.2) |
5 (20.8) |
|
| Liver metastasis |
244 |
201 |
43 |
0.294 |
| No |
79 |
68 (86.1) |
11 (13.9) |
|
| Yes |
165 |
133 (80.6) |
32 (19.4) |
|
| Lung metastasis |
244 |
201 |
43 |
0.323 |
| No |
166 |
134 (80.7) |
32 (19.3) |
|
| Yes |
78 |
67 (85.9) |
11 (14.1) |
|
| Lymph metastasis |
244 |
201 |
43 |
0.409 |
| No |
177 |
148 (83.6) |
29 (16.4) |
|
| Yes |
67 |
53 (79.1) |
14 (20.9) |
|
| Peritoneal metastasis |
244 |
201 |
43 |
0.846 |
| No |
196 |
161 (82.1) |
35 (17.9) |
|
| Yes |
48 |
40 (83.3) |
8 (16.7) |
|
| MSI |
240 |
189 |
41 |
0.774 |
| No |
226 |
187 (82.7) |
39 (17.3) |
|
| Yes |
14 |
12 (85.7) |
2 (14.3) |
|
|
KRAS mutations |
246 |
203 |
43 |
0.873 |
| No |
140 |
116 (82.9) |
24 (17.1) |
|
| Yes | 106 | 87 (72.1) | 19 (17.9) |
Abbreviations: ECOG=Eastern Cooperative Oncology Group; MSI=magnetic source imaging; p-PP2A=protein phosphatase 2A. P values in bold font indicate differences statistically significant.