Table 2. Univariate and multivariate Cox analyses in the cohort of 243 patients with mCRC.
|
Univariate OS analysis |
Multivariate OS Cox analysis |
|||||
|---|---|---|---|---|---|---|
| HR | 95% CI Lower–upper | Significance | HR | 95% CI Lower–upper | Significance | |
| Age |
|
|
<0.001 |
|
|
0.249 |
| |
1.000 |
|
|
1.000 |
|
|
| |
1.875 |
1.352–2.599 |
|
1.250 |
0.855–1.827 |
|
| Gender |
|
|
0.311 |
|
— |
|
| Male |
1.000 |
|
|
|
|
|
| Female |
0.848 |
0.616–1.167 |
|
— |
— |
|
| Synchronous |
|
|
0.118 |
|
— |
|
| No |
1.000 |
|
|
|
|
|
| Yes |
1.301 |
0.935–1.811 |
|
— |
— |
|
| ECOG |
|
|
<0.001 |
|
|
<0.001 |
| 0–1 |
1.000 |
|
|
1.000 |
|
|
| 2–3 |
1.925 |
1.588–2.333 |
|
1.777 |
1.427–2.213 |
|
| MSI |
|
|
0.450 |
|
— |
|
| No |
1.000 |
|
|
|
|
|
| Yes |
1.281 |
0.674–2.437 |
|
— |
— |
|
| Number of metastatic sites |
|
|
0.076 |
|
— |
|
| 1–2 |
1.000 |
|
|
|
|
|
| >2 |
1.250 |
0.977–1.600 |
|
— |
— |
|
| p-PP2A |
|
|
<0.001 |
|
|
<0.001 |
| No |
1.000 |
|
|
1.000 |
|
|
| Yes | 2.838 | 1.935–4.164 | 2.743 | 1.819–4.138 | ||
Abbreviations: CI=confidence interval; HR=hazard ratio; OS=overall survival; MSI=magnetic source imaging; p-PP2A=protein phosphatase 2A. P values in bold font indicate differences statistically significant.