Table 2.
Kinase selectivity profile of GNF-7: Enzymatic activity (% inhibition) of GNF-7 at 10 uM
| 0 | MAPKAP-K2(h) | 31 | Aurora-A(h) |
| 58 | MEK1(h) | 69 | Axl(h) |
| 98 | MKK4(m) | 98 | Bmx(h) |
| 100 | MKK6(h) | 100 | c-RAF(h) |
| 92 | p70S6K(h) | 0 | CaMKIV(h) |
| 45 | PAK2(h) | 3 | CDK1/cyclinB(h) |
| 62 | PDGFRα(h) | 12 | CHK2(h) |
| 0 | PDK1(h) | 6 | CK2(h) |
| 7 | PKBα(h) | 100 | CSK(h) |
| 51 | PKCα(h)-His | 98 | Fes(h) |
| 22 | PKCθ(h) | 100 | FGFR3(h) |
| 77 | PKD2(h) | 69 | Flt3(h) |
| 2 | ROCK-II(h) | 59 | GSK3β(h) |
| 95 | Rsk1(h) | 69 | IKKα(h) |
| 95 | SAPK2a(h) | 49 | IKKβ(h) |
| 98 | SAPK2b(h) | 89 | IR(h) |
| 35 | SAPK3(h) | 97 | JNK1α1(h) |
| 0 | SGK(h) | 99 | JNK2α2(h) |
| 98 | Syk(h) | 99 | Lck(h) |
| 100 | TrkB(h) | 68 | MAPK1(h) |
| 6 | ZAP-70(h) |