Table 3.
The growth inhibitory potency (IC50, uM) of GNF-7
TPR-Met-Ba/F3 | NPM-ALK-Ba/F3 | JAK1-Ba/F3 | JAK2-Ba/F3 | JAK2-V617F-Ba/F3 | JAK3-Ba/F3 | FGFR3-Ba/F3 | Flt3-Ba/F3 | Flt3-ITD-Ba/F3 | PDGFRβ-Ba/F3 | TrkC-Ba/F3 | Colo205 | SW620 | U87 | HEK293T |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3.401 | 1.466 | 0.044 | 0.127 | 0.050 | 2.018 | 0.009 | 0.359 | 0.012 | 0.011 | 0.008 | 0.005 | 0.001 | 5.956 | >10 |