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. Author manuscript; available in PMC: 2015 Aug 14.
Published in final edited form as: Cell. 2014 Aug 14;158(4):849–860. doi: 10.1016/j.cell.2014.05.050

Figure 3. LCR dependence of βh1-globin induction by βh1-SA protein.

Figure 3

(A) Experimental concept. Testing the activity of βh1-SA in the absence of the LCR addresses whether it functions locally at the βh1-globin promoter or requires long range LCR looping for function. (B-D) mRNA levels of indicated genes were measured in S0 cells from wild type or ΔLCR/ΔLCR fetal liver cells expressing indicated constructs. Results were normalized to GAPDH. Error bars denote SEM. N=3. See also Figure S3.