Table 2.

Summary table of prognostic and genetic markers in serial CLL cases (time point 1)

	No/low evolution of DNA methylationn = 19 (%)	High evolution of DNA methylationn = 9 (%)	P
Prognostic indicators
IGHV unmutated	7 (37)	9 (100)	0.002
ZAP70 low methylation	7 (37)	9 (100)	0.002
High methylation heterogeneity	5 (26)	8 (89)	0.002
Cytogenetics
Normal karyotype	4 (21)	2 (22)	n.s.
Del 13q14	12 (63)	6 (67)	n.s.
Del 11q23	4 (21)	1 (11)	n.s.
Del 17p13	3 (16)	1 (11)	n.s.
Del 6q	1 (5)	1 (11)	n.s.
Trisomy 12	3 (16)	1 (11)	n.s.
Genetic mutations
TP53	3 (16)	5 (56)	0.03
SF3B1	4 (21)	3 (33)	n.s.
NOTCH	3 (16)	0	n.s.
MYD88	3 (16)	0	n.s.
BRAF	1 (5)	2 (22)	n.s.
KRAS	0	1 (11)	n.s.
Mutation clone size
Clonal (>80%)	7 (37)	1 (11)	n.s.
Subclonal (<80%)	5 (26)	6 (67)	0.04
Any	11 (58)	7 (78)	n.s.