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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: J Invest Dermatol. 2014 Apr 14;134(9):2438–2446. doi: 10.1038/jid.2014.186

Figure 5. Inhibition of arginase ameliorates the ear swelling of DNCB treated K14.E7 mice.

Figure 5

Mice were injected with 500 μg arginase inhibitor (nor-NOHA) or saline buffer one day prior to DNCB treatment and daily for 5 days. Arginase-1 mRNA expression (a) and arginase activity (b) in saline or nor-NOHA treated K14.E7 mice after 24 hours of exposure to DNCB, determined by real-time PCR and arginase assay, respectively. Ear swelling of K14.E7 mice treated with saline/nor-NOHA monitored during 5 days after DNCB treatment (c). Histological sections (d) and quantification of cell numbers infiltrating into the dermis from Nor-NOHA or saline treated K14.E7 skins one day following DNCB application (e). Means ± SEM, data show result from two independent experiments (n=5). *p<0.05, **p<0.01, *** p<0.001, ****p<0.0001, ns= not significant.