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. Author manuscript; available in PMC: 2015 Feb 15.
Published in final edited form as: Cancer Res. 2014 Jun 16;74(16):4378–4387. doi: 10.1158/0008-5472.CAN-14-0792

Figure 1. Generation of hGSTP1::LacZ mice.

Figure 1

The construct used to generate the of hGSTP1::LacZROSA26 mouse. Approximately 2.6 kb of the human GSTP1 promotor and the entire GSTP1 gene (~2.5kb) were cloned, fused in-frame with lacZ, into the ROSA26 gene locus by homologous recombination in C57BL/6 embryonic stem cells. Positions of known transcription factor binding sites, and previously reported regulators of gene induction or repression, are shown: cAMP/CRE; NF-kB; RA(32); AP-1/Sp1(18, 48, 49); Insulin(32, 50); p53(31); RA/RARE(50).