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. Author manuscript; available in PMC: 2015 Aug 15.
Published in final edited form as: Clin Cancer Res. 2014 Jun 11;20(16):4262–4273. doi: 10.1158/1078-0432.CCR-13-2627

Fig 6. PDL1 blockade and DGK inhibition are able to restore CAR TIL function.

Fig 6

10ug/ml of anti-PDL1 antibody was added to the co-culture killing assay and was able to restore (A) mesoCAR TIL killing of EMMESOffluc (B) and tumor-induced mesoCAR TIL secretion of IFNg after fresh isolation from flank tumor. (C) 1uM of type I and II DGK inhibitor was added to the co-culture killing assay and was able to restore mesoCAR TIL killing of EMMESOffluc with (D) minimal increase in tumor-induced mesoCAR TIL secretion of IFNg after fresh isolation from flank tumor. 25ug/ml of SSG was added to the co-culture killing assay and was able to restore (E) mesoCAR TIL killing of EMMESOffluc (F) and tumor-induced mesoCAR TIL secretion of IFNg after fresh isolation from flank tumor.