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. Author manuscript; available in PMC: 2015 Aug 18.
Published in final edited form as: Angew Chem Int Ed Engl. 2014 Jun 27;53(34):8980–8984. doi: 10.1002/anie.201405036

Table 2.

Ketene Surrogate Coupling Scope

graphic file with name nihms614731t3.jpg
[a]

Isolated yields over 2 steps. Reactions were conducted on a 0.3 mmol scale unless otherwise noted, 0.25 M in 1:1 (v:v) amine:ynol ether with 5 mol% Pd2(dba)3, 20 mol% phosphine, and 13 mol% of CuI for 12–24 h at rt.

[b]

3 mmol scale.

[c]

1 mmol scale.

[d]

48 h reaction time.