Table 4.
Comparison of key cytokines and growth factors in APS from OA patients and control donors. ND = nondetectible concentration of cytokine using ELISA assays. NA = not available due to non-detectible concentration of cytokine in whole blood.
| Cytokine | Baseline Concentration | APS Concentration (pg/ml) | Fold Increase | |
|---|---|---|---|---|
| IL-1ra | Control (n = 92) | 6,300 ± 3,000 | 39,000 ± 20,000 | 6.6 |
| OA (n = 99) | 7,600 ± 2,500 | 42,000 ± 20,000 | 5.9 | |
| sIL-IRII | Control (n = 51) | 10,000 ± 2,500 | 21,000 ± 5,000 | 2.1 |
| OA (n = 99) | 9,500 ± 2,500 | 21,000 ± 6,300 | 2.2 | |
| sTNF-RI | Control (n = 53) | 650 ± 490 | 2,100 ± 570 | 3.7 |
| OA (n = 99) | 810 ± 280 | 3,000 ± 960 | 3.9 | |
| sTNF-RII | Control (n = 64) | 1,000 ± 360 | 4,200 ± 1,500 | 4 |
| OA (n = 99) | 1,500 ± 490 | 5,100 ± 1,900 | 3.5 | |
| IL-1β | Control (n = 56) | 2.7 ± 1.2 | 7.2 ± 3.1 | 3 |
| OA (n = 99) | 3.3 ± 1.1 | 8.9 ± 7.3 | 2.8 | |
| TNFα | Control (n = 26) | ND | 1.7 ± 0.8 | NA |
| OA (n = 85) | ND | 4.3 ± 3.0 | NA | |
| IGF-1 | Control (n = 48) | 34,000 ± 37,000 | 52,000 ± 60,000 | 1.5 |
| OA (n = 98) | 79,000 ± 22,000 | 120,000 ± 43,000 | 1.5 | |