Table 2. Significantly altered circulating miRNAs in transgenic mice with mammary tumors.

Data were analyzed using miR-202 as a normalization control. Although miR-202 was present in all sera samples analyzed and showed least variability between samples, its levels were higher in the sera of MMTV-PyMT mice compared with control or MMTV-Her2/Neu mice.

	MMTV-Her2/Neu vs. control		MMTV-PyMT vs. control
miRNA	P value	Fold change	P value	Fold change
MMTV-Her2/Neu specific
miR-204	0.009	8.9	0.507	2.66
miR-375	0.017	2.82	0.712	−1.31
miR-381	0.02	3.2	0.375	−3.63
MMTV-PyMT specific
miR-450b-5p	0.43	1.18	0.01	−3.63
miR-142-3p	0.119	−2.02	0.01	−12.30
miR-150	0.073	−1.89	0.014	−3.41
miR-146b	0.397	2.59	0.018	6.16
Common to both
miR-486	0.0006	−5.69	0.001	−3.69