Table 2. Transmission disequilibrium test results for HTR2A polymorphisms in 158 CORA Trios.

Gene	dbSNP IDa	Minor Allele	Major Allele	HapMap CEU MAF	ASD MAF	Parent MAF	Total Trios	TDT Allele	Trans	Untrans	Chi Sq	p-value	Permuted p-valueb
HTR2A	rs6311	A	G	0.465	0.364	0.435	158	A	58	103	12.58	0.0004	0.0004
Excluding samples with pathogenic or likely pathogenic mutationsc							146	A	54	95	11.28	0.0008	0.0011
HTR2A	rs6314	T	C	0.062	0.117	0.106	158	T	34	27	0.80	0.3701	0.6417
Excluding samples with pathogenic or likely pathogenic mutationsc							146	T	32	25	0.86	0.3538	0.6174

^aNational Center for Biotechnology Information (NCBI) dbSNP build 137

^bcorrected p-value after 10,000 permutations

^cincludes PTEN and 22q11.2 mutations and samples listed in Supplemental Table 1.

Abbreviations – CEU: HapMap CEPH (Utah Residents with Northern and Western European Ancestry) population; CORA: Central Ohio Registry for Autism; MAF: minor allele frequency; TDT: transmission disequilibrium test; Trans: transmitted; Untrans: untransmitted