Table 3.
Smoking Status by Urine NNAL | ||||
---|---|---|---|---|
Nonsmoker 0 pg/ml (N=143) | Passive smoker >0, <47.3 pg/ml (N=101) | Active smoker >=47.3 pg/ml (N=137) | p-value | |
Lung Injury Score, mean ± SD | 2.7 ± 0.6 | 2.8 ± 0.6 | 2.8 ± 0.5 | 0.40 |
PaO2/FiO2 (mm Hg), mean ± SD | 121 ± 53 | 123 ± 60 | 130 ± 79 | 0.48 |
PEEP (cm H2O), mean ± SD | 8.8 ± 3.6 | 8.8 ± 3.6 | 9.3 ± 3.3 | 0.41 |
Compliance (mL/cm H2O), mean ± SD | 35 ± 16 | 33 ± 19 | 33 ± 14 | 0.45 |
CXR quadrants with opacities, median [IQR] | 4 [3, 4] | 4 [3, 4] | 4 [3, 4] | 0.44 |
Oxygenation Index, median [IQR] | 10 [6, 16] | 13 [7 , 21] | 11 [8, 18] | 0.20 |
Berlin Definition of ARDS, n (%) | 0.37 | |||
Mild ARDS (n=42) | 11 (8) | 14 (14) | 17 (13) | |
Moderate ARDS (n=178) | 73 (53) | 41 (41) | 64 (48) | |
Severe ARDS (n=152) | 55 (40) | 44 (44) | 53 (40) |
Definition of abbreviations: FiO2 = fraction of inspired oxygen; NNAL = 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; PaO2 = partial pressure of oxygen in arterial blood; PEEP = positive end-expiratory pressure; SD = standard deviation