Table 4.
Smoking Status Stratified by Urine NNAL | ||||
---|---|---|---|---|
Outcome | Nonsmoker 0 pg/ml (N=143) | Passive smoker >0, <47.3 pg/ml (N=101) | Active smoker >=47.3 pg/ml (N=137) | p-value |
60-day mortality, n (%) | 42 (29) | 21 (21) | 21 (15) a | 0.02 |
Ventilator-free days, median (IQR) b | 18 [0, 25] | 21 [0, 24] | 21 [13, 25] a | 0.10 |
Organ failure-free days, median (IQR) b | 5 [0, 21] | 6 [0, 19] | 13 [0, 23] a | 0.03 |
Cardiovascular failure free days, median (IQR) | 23 [12, 27] | 25 [16, 27] | 25 [18, 27] | 0.27 |
Coagulation failure free days, median (IQR) | 28 [20, 28] | 28 [22, 28] | 28 [26, 28] a | 0.01 |
Renal failure free days, median (IQR) | 28 [9, 28] | 28 [13, 28] | 28 [21, 28] a | 0.05 |
Hepatic failure free days, median (IQR) | 28 [18, 28] | 28 [19, 28] | 28 [27, 28] a | 0.03 |
Definition of abbreviations: NNAL = 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
Active smoker vs nonsmoker p<0.05
Ventilator-free and organ failure-free days are from time of randomization to day 28 of enrollment