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Monocytic leukemia developed in the PTEN knockout mice was transplantable. (a) Illustration of the strategy used for leukemic cell transfer. (b) Leukemic blasts are present in bone marrow and spleen of recipient mice. Leukemic blasts are marked by black arrows in BM. (c) FACS analysis showed a significant amount of leukemic cells (CD45.2+) in bone marrow and peripheral blood of the recipient mice.
