Table 1.

Time-course of ¹¹C radioactivity in peripheral organs and tissues of the rat following [¹¹C]-3-PHNO injection. Awake rats were administered ~280μCi [¹¹C]-3-PHNO i.v. and were euthanized 2, 10, 30 or 60 minutes later (3 rats at each time-point). ¹¹C activity was counted in peripheral organs and tissues and expressed as uptake units (mean ± SD).

Sample	2 min	10 min	30 min	60 min
Heart	2.48±0.23	0.85±0.15	0.51±0.26	0.25±0.00
Lung	9.55±0.96	3.93±1.01	1.62±0.57	1.08±0.10
Liver	2.76±0.47	3.03±0.65	3.13±1.01	1.73±0.21
Kidney	7.69±0.38	2.87±0.10	1.44±0.28	1.05±0.23
Spleen	3.91±0.45	2.38±0.33	0.70±0.16	0.46±0.03
Stomach	1.68±0.45	1.05±0.18	1.36±0.78	0.38±0.15
Small intestine	3.68±1.09	3.36±1.15	4.60±3.96	1.55±1.14
Small intestine content	10.83±5.20	15.54±12.33	11.11±7.71	7.05±2.17
Large intestine	1.97±0.54	0.87±0.12	0.55±0.04	1.12±1.42
Large intestine content	0.18±0.17	0.15±0.11	1.19±1.91	0.11±0.15
Testes	1.07±0.26	1.13±0.08	0.87±0.06	0.47±0.04
Skeletal muscle	0.56±0.12	0.48±0.05	0.3±0.01	0.17±0.02
Fat	0.48±0.33	0.44±0.16	0.62±0.05	0.39±0.04
Skin	0.64±0.21	0.40±0.14	0.40±0.02	0.25±0.06
Urine	0.53±0.23	2.88±15.97	20.27±8.14	16.85±9.18
Whole blood	0.54±0.20	0.40±0.00	0.26±0.08	0.16±0.05
Plasma	0.60±0.12	0.47±0.09	0.29±0.02	0.25±0.00