Table 2.

Time-course of ¹¹C radioactivity in brain regions of the rat following [¹¹C]-3-PHNO injection. Awake rats were administered ~280μCi [¹¹C]-3-PHNO i.v. and were euthanized 2, 10, 30 or 60 minutes later (3 rats at each time-point). ¹¹C activity was counted in dissected brain regions and expressed as both mean±SD uptake units and mean±SD ‘specific’ binding ratio relative to the cerebellum (SBR: (uptake units_(ROI) – uptake units_(cerebellum))/( uptake units_(cerebellum)).

Region		2 min	10 min	30 min	60 min
Striatum	Uptake units SBR	3.66±0.55 0.24±0.14	4.38±0.57 1.57±.43	4.15±0.52 4.41±.35	2.17±0.28 3.73±0.60
Olfactory bulbs	Uptake units SBR	3.50±0.41 0.19±0.07	2.53±0.59 0.49±0.40	2.07±0.11 1.73±0.33	1.08±0.06 1.36±0.24
Olfactory tubercles	Uptake units SBR	3.69±0.56 0.25±0.11	2.55±0.09 0.49±0.09	1.42±0.17 0.86±0.30	0.85±0.11 0.84±0.18
Thalamus	Uptake units SBR	3.51±0.44 0.19±0.07	1.45±0.11 0.29±0.15	1.01±0.14 0.31±0.06	0.62±0.04 0.35±0.08
Hypothalamus	Uptake units SBR	3.86±0.61 0.31±0.16	1.49±0.11 0.31±0.02	0.97±0.01 0.27±0.44	0.66±0.02 0.44±0.09
Prefrontal cortex	Uptake units SBR	3.66±0.37 0.24±0.05	2.00±0.12 0.17±0.01	0.82±0.07 0.07±0.02	0.46±0.00 0.01±0.04
Somatosensory cortex	Uptake units SBR	3.61±0.20 0.23±0.09	1.87±0.09 0.09±0.03	0.89±0.17 0.16±0.12	0.51±0.01 0.10±0.06
Entorhinal cortex	Uptake units SBR	3.13±0.50 0.06±0.10	1.82±0.04 0.06±0.03	0.72±0.02 −0.05±0.09	0.43±0.03 −0.07±0.04
Hippocampus	Uptake units SBR	2.43±0.10 −0.17±0.03	1.74±0.07 0.01±0.03	0.76±0.07 −0.00±0.00	0.40±0.01 −0.12±0.02
Medulla with Pons	Uptake units SBR	3.34±0.30 0.13±0.05	2.09±0.07 0.22±0.04	0.95±0.09 0.25±0.04	0.48±0.02 0.04±0.02
Inferior colliculi	Uptake units SBR	5.09±0.64 0.72±0.16	2.59±0.10 0.51±0.11	1.17±0.06 0.54±0.15	0.71±0.05 0.54±0.12
Superior colliculi	Uptake units SBR	3.69±0.44 0.25±0.07	2.41±0.29 0.41±0.08	1.22±0.11 0.60±0.08	0.71±0.04 0.55±0.12
Cerebellum	Uptake units	2.95±0.20	1.72±0.09	0.77±0.07	0.46±0.02