Table 4.
Regional [11C]-3-PHNO specific binding ratio (SBR) estimates calculated using non-displaceable (ND) estimates from cerebellar uptake units, PHNO blocking data or raclopride blocking data. When BP values are calculated from cerebellar uptake units, SBRs are underestimated due to the presence of specific binding in the cerebellum. SBR estimates obtained via graphical analysis of PHNO and raclopride occupancy data represent ‘true’ values.
| Calculated specific binding ratio | |||
|---|---|---|---|
|
| |||
| ND estimated from cerebellar uptake units | ND estimated from PHNO block | ND estimated from raclopride block | |
| Striata | 3.723 | 5.358 | 5.184 |
| Olfactory bulbs | 0.576 | 2.173 | 2.086 |
| Olfactory tubercles | 0.843 | 1.481 | 1.413 |
| Thalamus | 0.351 | 0.818 | 0.769 |
| Hypothalamus | 0.438 | 0.935 | 0.883 |
| Prefrontal cortex | 0.004 | 0.352 | 0.315 |
| Somatosensory cortex | 0.100 | 0.481 | 0.440 |
| Entorhinal cortex | −0.070 | 0.252 | 0.218 |
| Hippocampus | −0.124 | 0.179 | 0.147 |
| Medulla with Pons | 0.538 | 1.070 | 1.014 |
| Inferior colliculi | 0.545 | 1.079 | 1.022 |
| Superior colliculi | 0.037 | 0.396 | 0.358 |
| Cerebellum | (0) | 0.346 | 0.309 |