Table 5.
Time-course of composition of radioactive species in plasma and brain. The table presents the percentage of 11C radioactivity occurring as unmetabolized parent compound ([11C]-3-PHNO) or a polar radiolabeled metabolite (M1). Data at each time-point was obtained in a single animal.
| % Metabolite (M1) | % Intact parent compound | |
|---|---|---|
| Plasma | ||
|
| ||
| 2 min | 52.18 | 47.82 |
| 10 min | 68.27 | 31.73 |
| 20 min | 74.55 | 25.45 |
| 30 min | 71.40 | 28.60 |
| 60 min | 86.99 | 13.01 |
| Brain | ||
|
| ||
| 10 min | 3.46 | 96.54 |
| 30 min | 3.36 | 96.64 |
| 60 min | 6.95 | 93.05 |