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. Author manuscript; available in PMC: 2015 Aug 28.
Published in final edited form as: Org Biomol Chem. 2014 Jul 3;12(32):6190–6199. doi: 10.1039/c4ob01088d

Table 2.

Scope of the trifluoromethylation reaction of heterocyclic N-oxides.a

graphic file with name nihms611330f4.jpg
a

Reaction conditions: heterocyclic N-oxide (0.2 or 0.5 mmol), 1 (1.5 equiv), KOt-Bu (3 equiv), 3Å MS, THF (c=0.2 M), at −20 °C under Ar for 50 min.