. Author manuscript; available in PMC: 2014 Aug 17.

Published in final edited form as: Pharmacol Biochem Behav. 2007 Dec 8;89(2):137–144. doi: 10.1016/j.pbb.2007.12.002

Table 2.

Alcohol dehydrogenase activities in liver and brain

	ADH Activities (U/mg protein) at Postnatal Age
Organ, Isozyme	P25 LE	P90 LE
Liver ADH-3	0.036 ± 0.001^*	0.025 ± 0.002
Liver ADH-2	0.015 ± 0.001^*	0.011 ± 0.001
Brain ADH-2	0.0026 ± 0.0002	0.0025 ± 0.0001

Liver and brain alcohol dehydrogenase (ADH) were determined using different substrates to distinguish ADH isozymes, ADH-2 and ADH-3. Tissues were all from ethanol-naive Long-Evans rats at two postnatal ages, P25 (juvenile) and P90 (adult). Activity is expressed in Units (μmoles NADH produced/min) and values presented are mean±SD (N=6).

Liver ADH-2 and ADH-3 were significantly greater (p<0.001) in liver preparations from P25 compared to P90 rats. There was no significant difference in Brain ADH-2 levels.