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Mean ± SD Pharmacokinetic Parameters for Plasma 5-FU*
| 5-FU Maintenance Dose (mg/m2) | Vorinostat Dose (mg) | Css (ηg/mL) | Cmax (ηg/mL) | AUC (ηg* hr/mL) |
|---|---|---|---|---|
| 2400 | 100 | 0.287 ± 0.044 | 5.03 ± 4.39 | 15.3 ± 5.7 |
| 2400 | 200 | 0.274 ± 0.045 | 13.1 ± 7.96 | 24 ± 9.11 |
| 2400 | 300 | 0.396 ± 0.159 | 24.5 ± 14.5 | 68.7 ± 88.1 |
| 2400 | 400 | 0.432 ± 0.077 | 26.8 ± 11.4 | 46.7 ± 10.6 |
ANOVA analysis was performed and only Cmax was statistically significant among the vorinostat treatment groups.
