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. Author manuscript; available in PMC: 2014 Aug 17.

Published in final edited form as: Clin Cancer Res. 2009 Apr 21;15(9):3189–3195. doi: 10.1158/1078-0432.CCR-08-2999

Table 6.

Pharmacokinetic Parameters for Vorinostat on Days 1 and 5

		Day 1					Day 5
Dose (mg)		Cmax (μM)	Tmax (h)	AUC (μM*h)	t1/2 (h)	CLapp (l/h)	Cmax (μM)	Tmax (h)	AUC (μM*h)	t1/2 (h)	CLapp (l/h)

100	Mean	1.241	2.4	2.5	1.5	189	0.702	3.4	1.9	1.2	202
100	SD	1.061	1.9	1.2	0.9	102	0.342	3.4	0.4	0.3	60
200	Mean	0.816	1.5	1.9	1.2	400	0.894	2.7	3.3	1.6	231
200	SD	0.245	0.9	0.3	0.3	54	0.540	1.2	0.6	0.7	39
300	Mean	1.458	1.6	4.4	2.3	285	0.950	2.4	6.8	2.3	225
300	SD	0.712	1.1	1.5	2.0	83	0.590	1.1	4.3	1.1	118
400	Mean	1.511	1.9	4.5	3.7	345	1.475	2.8	7.4	2.2	211
400	SD	0.533	1.5	0.6	3.5	48	0.363	1.5	1.4	1.4	40