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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: J Immunol. 2014 Jul 25;193(5):2519–2530. doi: 10.4049/jimmunol.1400276

Figure 4. Complement Receptor 3 is critical for β-glucan induced inflammasome activation and IL-1β production.

Figure 4

Pam2CSK4 primed BMDC from C57BL/6, Itgam−/− mice were stimulated with curdlan (I) for 6h or ATP for 1h. IL-1β released in the supernatants was measured by ELISA (A). Cells were stimulated as indicated, precipitated supernatants and lysates were probed for IL-1β or caspase-1 p20 (B). Statistical analysis was performed on results in panel A as described in the Materials and Methods section.