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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: J Immunol. 2014 Jul 25;193(5):2519–2530. doi: 10.4049/jimmunol.1400276

Figure 5. Caspase-8 promotes β-glucan induced IL-1β maturation.

Figure 5

Pam2CSK4 primed BMDC from C57BL/6, littermate Rip3−/−, Casp8−/−Rip3−/− mice were stimulated with β-glucans for 24h, FasL, pdAdT for 6h (A) or as indicated (B). IL-1β released in the supernatants was measured by ELISA (A, B). Cells were stimulated as indicated and precipitated supernatants and lysates were probed for IL-1β, caspase-1 or caspase-8 (C, D). Statistical analysis was performed on results in panels A and B as described in the Materials and Methods section.