Skip to main content
. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Prog Retin Eye Res. 2014 Jun 28;42:44–84. doi: 10.1016/j.preteyeres.2014.06.003

Figure 1. Schematic organization of neurons in the mammalian retina.

Figure 1

(Left) Vertical section of mouse retina showing labeling of the major neuronal cell types. Immunostaining for cone photoreceptors (anti-cone arrestin, blue), horizontal cells (anti-calbindin, pink), bipolar cell terminals (anti-synatotagmin2 and anti-PKC, red), amacrine cells (anti-calretinin, purple), and ganglion cells (SMI-32, white). Immunolabeling was performed on a retina from a transgenic line in which a subtype of bipolar cell (ON-type) express yellow fluorescent protein (green). ONL: outer nuclear layer, OPL: outer plexiform layer, INL: inner nuclear layer, IPL: inner plexiform layer and GCL: ganglion cell layer.

(Right) Schematic of the retina. R: rod photoreceptor, C: cone photoreceptor, HC: horizontal cell, BC: bipolar cell, AC: amacrine cell, RGC: retinal ganglion cell. The rod pathway (cells shaded in grey) conveys scotopic information to the photopic cone pathway, via the AII amacrine cell. Colored cells represent cone pathways. Neurons that are depolarized by light increments restrict their synaptic connectivity to the ON sublamina of the IPL, whereas connections of cells that are hyperpolarized instead form the OFF sublamima.