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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Prog Retin Eye Res. 2014 Jun 28;42:44–84. doi: 10.1016/j.preteyeres.2014.06.003

Figure 16. Role of neurotransmission in regulating synaptic connectivity in the mouse IPL.

Figure 16

(A) Synapse number between cone bipolar cells (CBC) and ganglion cells (RGC) is regulated by neurotransmission. Type 6 bipolar cells that express tetanus toxin (TeNT) make fewer synapses with dendrites of large-field ON alpha-like ganglion cells compared to wildtype (WT) bipolar cells (Kerschensteiner et al., 2009; Morgan et al., 2011; Okawa et al., 2014).

(B) GABAergic neurotransmission is necessary for maintaining specific GABA receptor subtypes on rod bipolar cell (RBC) axon terminals. Impairing inhibitory neurotransmission from amacrine cells (ACs) in the GAD67 (GABA synthetic enzyme) deficient (GAD1 mutant) retina leads to a reduction in GABAA but not GABAC receptors on RBC axon terminals (Schubert et al., 2013).