A, Dose–response relationships for protection by 5α,3α-A and ent-5α,3α-A in the maximal electroshock (MES; 50 mA, 0.2 s, 60 Hz) test. Steroids were administered 15 min before electrical stimulation. Data points indicate percentage of animals protected against seizures. Each point represents eight mice. B, Dose–response relationships for protection by 5β,3α-A and ent-5β,3α-A in the MES test. Each point represents eight mice.