. Author manuscript; available in PMC: 2015 Sep 1.

Published in final edited form as: Psychopharmacology (Berl). 2014 Apr 5;231(17):3325–3332. doi: 10.1007/s00213-014-3546-x

Table 1.

ED₅₀ values of androsterone (5α,3α-A), ent-androsterone (ent-5α,3α-A), etiocholanolone (5β,3α-A) and ent-etiocholanolone (ent-5β,3α-A) for protection in the 6-Hz electrical stimulation, pentylenetetrazol (PTZ) and maximal electroshock (MES) seizure tests in mice

Steroid	ED50 (95% confidence intervals), mg/kg^a [PI^b]
Steroid	6-Hz	PTZ	MES
5α,3α-A	12.10 (6.04–24.30) [15.13]	51.80 (32.57–82.46) [3.53]	222.90 (180.20–275.80) [0.82]
ent-5α,3α-A	4.95 (1.40–17.60) [14.18]	22.80 (18.40–28.10) [3.08]	140.10 (115.13–170.43) [0.50]
5β,3α-A	57.57 (39.60–83.70) [2.61]	109.07 (100.31–118.60) [1.37]	177.07 (118.34–264.94) [0.85]
ent-5β,3α-A	11.78 (5.98–23.20) [3.07]	20.38 (13.70–30.32) [1.78]	89.87 (79.05–102.16) [0.40]

ED₅₀ values (with 95% confidence intervals in parentheses) represent the dose in mg/kg that is estimated to protect 50% of animals.

PI (protective index) is the ratio between TD₅₀ (the dose estimated to produce motor impairment in 50% of animals in the horizontal screen test) value and the ED₅₀ value. The TD₅₀ values (95% confidence intervals) for 5α,3α-A and ent-5α,3α-A were 183.1 (136.5–245.8) mg/kg and 70.2 (42.6– 115.6) mg/kg, respectively. The TD₅₀ values for 5β,3α-A and ent-5β,3α-A were 150.0 (84.1–267.4) mg/kg and 36.2 (24.1–54.4) mg/kg, respectively.