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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: J Immunol. 2014 Jul 28;193(5):2455–2468. doi: 10.4049/jimmunol.1400752

FIGURE 1.

FIGURE 1

Substantial decrease in the CDA of anti-CII mAb-induced arthritis by pretreatment with AdhMAp44. Higher (HD) and lower (LD) doses of AdhMAp44 particles were used. A. Prevalence of arthritis (%) over the duration of the experiment. B. CDA over the duration of the experiment. Black arrows show the injection time of AdhMAp44 or AdGFP at days -5, 0 and 3. *p < 0.05 in comparison with AdGFP treatment for data in B. C. All joint mean (AJM) histopathologic scores for inflammation (black solid bar), pannus formation (white hatched bar), cartilage damage (white empty bar) and bone damage (white line bar) from the five joints (2 forepaws, right hind knee, right hind ankle and right hind paw) was performed following tissue processing and toluidine-blue staining of sections. D. AJM for C3 deposition in the five joints examined within the synovium (black solid bar), on the surface of cartilage (white empty bar), and total score (white line bar) is presented. The data are expressed as mean of disease ± SEM (n = 5 each time point). *p values for specific histologic scoring results in C and D are included in the Results.