Figure 4.
Effect of JNK inhibitor (JNKi) treatment on CD4+CD25+ T cell-enhancement of lung allergic responses. Isolated CD4+CD25+ T cells were pretreated with active or inactive inhibitor in vitro and washed extensively prior to adoptive transfer into sensitized and challenged CD8−/− recipients. A: AHR, B: BAL cell composition, C: BAL cytokine levels. Results shown are means±SEM from 3 independent experiments, n=12. †p<0.05 comparing sensitized and challenged mice to mice challenged alone. *p<0.05 comparing recipients of CD4+CD25+ T cells to those which received PBS. #p<0.05 comparing recipients of inactive inhibitor-treated cells to active inhibitor-treated CD4+CD25+ T cells.