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Description of the 4 experimental groups: The difference in 4 experimental groups is described including the antibody for costimulation blockade and B cell depletion in each group.
| Group | Pig Genetics | n | Costimulation Blockade | B Cell Depletion |
|---|---|---|---|---|
| A | GTKO.hCD46Tg | 8 | Anti-CD154 (5C8) | Anti-CD20 |
| B | GTKO.hCD46Tg | 3 | Anti-CD40 (3A8) | Anti-CD20 |
| C | GTKO.hCD46Tg | 6 | Anti-CD40 (2C10) Low dose | Anti-CD20 |
| D | GTKO.hCD46Tg.hTBM | 5 | Anti-CD40 (2C10) High dose | Anti-CD20 |
