Table 4.
Change in Heart Rate | BAES Stimulation | BAES Sedation | |||||||
---|---|---|---|---|---|---|---|---|---|
Factor | df | F | p-value | df | F | p-value | df | F | p-value |
Alcohol | 1, 697 | 208.7 | <0.001 | 1, 704 | 125.4 | <0.001 | 1, 705 | 110.9 | <0.001 |
Time | 5, 697 | 17.0 | <0.001 | 1, 704 | 83.2 | <0.001 | 1, 704 | 30.0 | <0.001 |
Alcohol x Time | 5, 697 | 3.2 | 0.008 | 1, 704 | 59.6 | <0.001 | 1, 704 | 18.9 | <0.001 |
AKR1C3*2 | 1, 59 | 1.0 | 0.325 | 1, 59 | 5.4 | 0.024 | 1, 59 | 0.75 | 0.391 |
Alcohol x AKR1C3*2 | 1, 697 | 37.9 | <0.0012 | 1, 704 | 17.7 | <0.0012 | 1, 706 | 10.3 | 0.0012 |
SRD5A1 genotype | 2, 59 | 0.9 | 0.408 | 2, 58 | 0.05 | 0.954 | 2, 59 | 0.12 | 0.887 |
Alcohol x SRD5A1 | 2, 697 | 10.6 | <0.0012 | 2, 704 | 0.04 | 0.960 | 2, 706 | 0.96 | 0.377 |
AKR1C3*2 x SRD5A1 | 2, 59 | 0.2 | 0.819 | 2, 58 | 0.46 | 0.631 | 2, 59 | 0.12 | 0.884 |
Alc x AKR1C3*2 x SRD5A1 | 2, 697 | 1.9 | 0.147 | 2, 704 | 3.5 | 0.029 | 2, 706 | 0.28 | 0.760 |
AKR1C3*2 genotype coded as 0 for CC (n=25) or 1 for G-carriers (n=40) and for SRD5A1 genotype the number of minor C-alleles as 0 (n=16), 1 (n=36) or 2 (n= 13).
Alcohol x genotype significant model term results are bolded (p<0.01).