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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Psychopharmacology (Berl). 2014 May 17;231(17):3597–3608. doi: 10.1007/s00213-014-3614-2

Table 4.

Mixed Model results using AKR1C3*2 and SRD5A1 rs248793 genotypes1 as predictors of alcohol effects.

Change in Heart Rate BAES Stimulation BAES Sedation
Factor df F p-value df F p-value df F p-value
Alcohol 1, 697 208.7 <0.001 1, 704 125.4 <0.001 1, 705 110.9 <0.001
Time 5, 697 17.0 <0.001 1, 704 83.2 <0.001 1, 704 30.0 <0.001
Alcohol x Time 5, 697 3.2 0.008 1, 704 59.6 <0.001 1, 704 18.9 <0.001
AKR1C3*2 1, 59 1.0 0.325 1, 59 5.4 0.024 1, 59 0.75 0.391
Alcohol x AKR1C3*2 1, 697 37.9 <0.0012 1, 704 17.7 <0.0012 1, 706 10.3 0.0012
SRD5A1 genotype 2, 59 0.9 0.408 2, 58 0.05 0.954 2, 59 0.12 0.887
Alcohol x SRD5A1 2, 697 10.6 <0.0012 2, 704 0.04 0.960 2, 706 0.96 0.377
AKR1C3*2 x SRD5A1 2, 59 0.2 0.819 2, 58 0.46 0.631 2, 59 0.12 0.884
Alc x AKR1C3*2 x SRD5A1 2, 697 1.9 0.147 2, 704 3.5 0.029 2, 706 0.28 0.760
1

AKR1C3*2 genotype coded as 0 for CC (n=25) or 1 for G-carriers (n=40) and for SRD5A1 genotype the number of minor C-alleles as 0 (n=16), 1 (n=36) or 2 (n= 13).

2

Alcohol x genotype significant model term results are bolded (p<0.01).