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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Psychopharmacology (Berl). 2014 May 7;231(17):3503–3515. doi: 10.1007/s00213-014-3588-0

Figure 4. Epipregnanolone slows recovery from inactivation of T-currents in rat DRG cells.

Figure 4

a: Representative original current traces of a DRG cell in control conditions (top panel) and after 5 minutes of bath application of 10 μM epipregnanolone (bottom panel). b: Symbols indicate averaged data from multiple DRG cells (n = 8) that were fitted with a single exponential equation (solid lines). Recovery in control predrug conditions (black symbols and black solid line) was best described with τ of 800 ± 80 msec. After application of epipregnanolone in the same DRG cells (gray symbols and gray solid line) τ was about 2-fold slower: 1700 ± 200 msec. Symbol * indicates significance of p < 0.05.