Skip to main content
. Author manuscript; available in PMC: 2014 Aug 18.
Published in final edited form as: Mol Nutr Food Res. 2011 Jun 29;55(8):1249–1265. doi: 10.1002/mnfr.201100122

Table 3.

Selective inhibition of NFκB mediated by resveratrol derivatives.

Compounds tested IC50 (μM)a
28b graphic file with name nihms609730t28.jpg 0.2±0.09
29 graphic file with name nihms609730t29.jpg 1.1±0.23
30b graphic file with name nihms609730t30.jpg 2.5±0.16
31b graphic file with name nihms609730t31.jpg 1.0±0.19
32 graphic file with name nihms609730t32.jpg 0.7±0.11
33b graphic file with name nihms609730t33.jpg 0.5±15
a

Sample concentration which caused 50% inhibition of TNF-induced NFκB activity treated with solvent (DMSO) only. N-Tosyl-L- phenylalanine-chloromethyl ketone (TPCK) and BAY-11 were used as a positive controls (IC50 = 3.8 and 2.0 μM, respectively).

b

Compounds 28, 30, 31, and 33 inhibited COX-1 with IC50 values of 0.87±0.04, 0.68±0.2, 2.8±0.67, and 2.0±0.57 μM, respectively. Compound 31 inhibited COX-2 with and IC50 value of 7.5±1.6 μM.