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. Author manuscript; available in PMC: 2014 Aug 18.
Published in final edited form as: Mol Nutr Food Res. 2011 Jun 29;55(8):1249–1265. doi: 10.1002/mnfr.201100122

Table 5.

Selective inhibition of TPA-induced ODC activity by resveratrol derivatives.

Compounds tested IC50 (μM)*
37b graphic file with name nihms609730t37.jpg 1.2±0.22
38 graphic file with name nihms609730t38.jpg 1.0±0.16
39 graphic file with name nihms609730t39.jpg 0.9±0.24
40b graphic file with name nihms609730t40.jpg 0.9±0.15
41 graphic file with name nihms609730t41.jpg 0.8±0.14
42b graphic file with name nihms609730t42.jpg 2.1±0.38
a

Concentration which caused 50% TPA-induced ODC activity. Apigenin (IC50 = 6.0 μM), menadione (IC50 = 8.3 μM), and deguelin (IC50 = 0.1 μM) were used as positive controls.

b

Compounds 37, 40, and 42 inhibited COX-1 with IC50 values of 1.19±0.18, 1.92±1.3, and 1.54±0.64 μM, respectively. Compound 37 inhibited COX-2 with and IC50 value of 1.41±0.51 μM.