Table 2. Genetic characterization of VU-DIPG-3 and -5 human tumors and murine xenografts.

DNA from m-VU-DIPG-3 and -5 was isolated from subcutaneous tumor at transplant generation 1 and 2, respectively. n.a.: not analyzable.

	VU-DIPG-3		VU-DIPG-5
	human	murine	human	murine
Specific mutation
H3F3A K27M	+	−	+	−
H3F3A G34R	−	−	−	−
HIST1H3B K27M	−	−	−	−
PI3KCA H1047R	−	−	−	−
PI3KCA H1047L	−	−	−	−
PI3KCA E542K	−	−	−	−
Amplification
EGFR	−	−	n.a.	n.a.
PTEN	−	−	Deletion	n.a.
PDGFR-α	−	−	n.a.	n.a.
Array CGH profile
Human 180K	Gain 1q, loss 17p (distal)	n.a.	n.a.	n.a.
Mouse 180K	n.a.	Loss 4 (C4-C5), gain 4 (C5-D2.2)	n.a.	n.a.