Table 1.

Distribution of concentration-effect curves for control compounds. This table lists the fitted parameters for the pIC₅₀ (logistic) and Hill (log-logistic) distributions for each control compound, for each cardiac ion channel assay.

Ion channel	Control compound	HTS platform	Performed at	Repeats N	pIC50 Logistic		Hill Log-logistic
					μ	σ	α	1/β
NaV1.5	Flecainide	IonWorks	AZ	2307	5.235	0.0760	1.188	0.0835
NaV1.5	Amitryptiline	IonWorks	GSK	362	5.765	0.1388	1.744	0.1983
NaV1.5	Tetracaine	IonWorks	GSK	248	6.060	0.1459	1.530	0.2089
NaV1.5	GSK-A	IonWorks	GSK	121	5.315	0.2044	0.930	0.1529
CaV1.2	Verapamil	IonWorks	AZ	369	5.571	0.1597	0.605	0.1206
CaV1.2	Nicardipine	FLIPR	GSK	395	7.378	0.2216	1.325	0.2386
CaV1.2	Nifedipine	FLIPR	GSK	328	7.248	0.1856	1.179	0.2213
CaV1.2	Diltiazem	FLIPR	GSK	244	5.249	0.1560	0.979	0.2263
hERG	Cisapride	IonWorks	AZ	12638	6.408	0.1034	1.790	0.1784
hERG	Quinidine	IonWorks	GSK	120	5.625	0.1033	1.708	0.1544
hERG	Pimozide	IonWorks	GSK	94	7.321	0.1914	1.586	0.2486
hERG	Haloperidol	IonWorks	GSK	84	6.852	0.1498	1.469	0.2031
hERG	Verapamil	IonWorks	GSK	72	6.169	0.1464	1.429	0.2025
IKs	XE991	IonWorks	AZ	525	6.217	0.1053	1.127	0.1510
IKs	XE991	IonWorks	GSK	79	5.927	0.1342	1.011	0.1837
IKs	GSK-B	IonWorks	GSK	451	7.414	0.1808	1.318	0.1677
Ito	Flecainide	IonWorks	AZ	366	4.860	0.0860	1.063	0.0862